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. 2017 Oct 27;8:852. doi: 10.3389/fphys.2017.00852

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Copyright © 2017 El Refaey and Mohler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure of ankyrins and ankyrin-binding partners. Ankyrins are formed of four distinct domains: a membrane-binding domain (MBD), a spectrin-binding domain (SBD), a death domain (DD) and a C-terminal domain (CTD). Each domain interacts with distinct ion channels, transporters and pumps. Ca_v1.3, calcium channel, voltage-dependent, L type, alpha 1D subunit; Na/K-ATPase, sodium/potassium ATPase; NCX, Na/Ca exchanger; InsP₃R, Inositol trisphosphate receptor; Kir6.2, Inward-rectifier potassium ion channel; Na_v channels, voltage-gated sodium channels; L1-CAMs, The L1 family of neural cell adhesion molecules; PP2A, protein phosphatase type 2A; Hsp40, Heat shock protein 40.