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. 2017 Oct 11;22:70. doi: 10.1186/s12199-017-0678-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Mutations in NLR that cause immune-related diseases. NOD1 variant E266K associated with sarcoidosis was found in Japanese population. Three mutations in NOD domain of NOD2 (R334W, R334Q, and L469F) exist both in Blau syndrome in Caucasians and EOS in Japanese cohort. NOD2 SNPs near or within the LRRs of Nod2 (R702W, G908R, L1007insC) are associated with the development of CD in Caucasians that does not exist in Japanese cohort