Table 7.
Findings from the Sapporo cohort on the associations between exposures and birth size
| Exposures | Outcome | Number | Findings | Reference |
|---|---|---|---|---|
| PCDD/PCDFs | Birth weight | 398 | Significant decrease. Individual congener assessment found 2,3,4,7,8-PeCDF had a significant negative influence (per log10 unit: β = −24.5 g, 95% CI −387.4 to −61.5). | [33] |
| PCBs | Birth weight | 367 | No association. | [36] |
| PFASs | Birth weight | 428 | PFOS was negatively correlated (per log10 unit: β = −269.4 g, 95% CI −465.7 to −73.0). | [34] |
| Ponderal index | 177 | PFOA was negatively associated (per log10 unit: β = −0.73 kg/m3, 95% CI −1.44 to −0.02). | [26] | |
| Cord adipokines | 168 | PFOS was positively associated with adiponectin (per log10 unit: β = 0.12, 95% CI 0.01 to 0.22). | [37] | |
| DEHP | Ponderal index | 167 | Significant decrease (per log10 unit: β = −1.28, 95% CI −2.43 to −0.13). | [35] |
| Cord adipokines | 167 | Significant decrease in leptin among girls (per log10 unit: β = −0.31, 95% CI −0.52 to −0.10). Significant increase in adiponectin among boys (per log10 unit: β = 4.63, 95% CI 0.77 to 8.49). | ||
| Me-Hg | Birth weight/SGA | 367 | No association with birth weight. The risk of SGA by weight decreased with increasing Me-Hg. | [36] |
PCDD polychlorinated dibenzo-p-dioxin, PCDF polychlorinated dibenzofuran, PCB polychlorinated biphenyls, PFASs perfluorinated alkyl substances, PFOS perfluorooctanoic sulfonate, PFOA perfluorooctanoic acid, DEHP di(2-ethylhexyl) phthalate, Me-Hg methylmercury, SGA small for gestational age