Table 3.
Geometric (arithmetic) mean counts of Ixodes ricinus and percent efficacy of lotilaner at 8 h following post-treatment challenge infestations (Group 1, control and Group 3, lotilaner)
| Day of challenge | Untreated control | Lotilaner | Comparison | ||||
|---|---|---|---|---|---|---|---|
| Mean (arithmetic) | Range | Mean (arithmetic) | Range | Efficacy (%) (arithmetic mean efficacy) | |||
| 7 | Before incubation | 14.4 (15.3) | 8–28 | 2.0 (2.8) | 0–8 | 86.1 (82.0) | t (7) = 6.76, P = 0.0003 |
| After incubation | 14.3 (15.1) | 8–28 | 0.2 (0.3) | 0–1 | 98.7 (98.3) | t(7) = 15.55, P < 0.0001 | |
| 14 | Before incubation | 16.7 (16.9) | 12–21 | 4.5 (6.0) | 0–11 | 73.2 (64.4) | t(7) = 3.78, P = 0.0069 |
| After incubation | 16.4 (16.6) | 12–21 | 0.4 (0.6) | 0–3 | 97.5 (96.2) | t(7) = 12.89, P < 0.0001 | |
| 21 | Before incubation | 11.7 (12.1) | 7–16 | 1.5 (2.0) | 0–5 | 87.3 (83.5) | t(7) = 6.23, P = 0.0004 |
| After incubation | 11.6 (12.0) | 7–15 | 0.5 (0.6) | 0–2 | 95.8 (94.8) | t(7) = 11.55, P < 0.0001 | |
| 28 | Before incubation | 9.9 (10.6) | 4–16 | 2.4 (3.4) | 0–7 | 75.9 (68.2) | t(7) = 4.55, P = 0.0026 |
| After incubation | 9.9 (10.6) | 4–16 | 0.6 (0.8) | 0–2 | 94.3 (92.9) | t(7) = 11.52, P < 0.0001 | |
| 35 | Before incubation | 6.5 (8.8) | 0–23 | 2.4 (3.3) | 0–11 | 63.4 (62.9) | t(7) = 2.25, P = 0.0590 |
| After incubation | 6.5 (8.6) | 0–22 | 0.9 (1.3) | 0–3 | 85.7 (85.5) | t(7) = 3.54, P = 0.0095 | |