Table 4.
Geometric (arithmetic) mean counts of Ixodes ricinus and percent efficacy of lotilaner at 12 h following post-treatment challenge infestations (Group 2, control and Group 4, lotilaner)
| Day of challenge | Untreated control | Lotilaner | Comparison | ||||
|---|---|---|---|---|---|---|---|
| Mean (arithmetic) | Range | Mean (arithmetic) | Range | Efficacy (%) (arithmetic mean efficacy) | |||
| 7 | Before incubation | 14.4 (14.9) | 10–23 | 1.0 (1.9) | 0–9 | 93.2 (87.4) | t (7) = 6.47, P = 0.0003 |
| After incubation | 14.4 (14.9) | 10–23 | 0.1 (0.1) | 0–1 | 99.4 (99.2) | t (7) = 20.98, P < 0.0001 | |
| 14 | Before incubation | 13.2 (13.6) | 9–17 | 0.6 (1.5) | 0–6 | 95.3 (89.0) | t (7) = 6.55, P = 0.0003 |
| After incubation | 13.1 (13.5) | 9–17 | 0.2 (0.3) | 0–1 | 98.6 (98.1) | t (7) = 17.21, P < 0.0001 | |
| 21 | Before incubation | 12.5 (12.9) | 8–18 | 0.6 (1.3) | 0–5 | 95.5 (90.3) | t (7) = 7.99, P < 0.0001 |
| After incubation | 12.5 (12.9) | 8–18 | 0.2 (0.3) | 0–1 | 98.5 (98.1) | t (7) = 21.49, P < 0.0001 | |
| 28 | Before incubation | 13.3 (13.8) | 8–20 | 0.3 (0.6) | 0–4 | 97.5 (95.5) | t (7) = 10.49, P < 0.0001 |
| After incubation | 12.8 (13.3) | 8–20 | 0.3 (0.4) | 0–2 | 98.0 (97.2) | t (7) = 13.28, P < 0.0001 | |
| 35 | Before incubation | 9.9 (10.4) | 5–17 | 1.5 (1.9) | 0–4 | 84.6 (81.9) | t (7) = 6.03, P = 0.0005 |
| After incubation | 9.8 (10.3) | 5–16 | 0.6 (0.8) | 0–2 | 94.2 (92.7) | t (7) = 10.59, P < 0.0001 | |