Table 4.
Effects of gene-environment interactions significant at 5% level between gene-specific trees and environmental factors on rectal cancer survival.
| GST | Gene | Chr. | Cases (%) | Gene HR a (95% CI) | Env. Factor | Category | N (%) b | Gene OR by Env. Factor a (95% CI) | HRINT c (95% CI) | PINT d |
|---|---|---|---|---|---|---|---|---|---|---|
| rs6838752 (TT or TC) | KDR | 4q12 | 705 (93.6%) | 0.89 (0.55, 1.45) | Protein e | Low | 258 (32.4%) | 0.44 (0.21, 0.91) | Ref | |
| High | 538 (67.6%) | 1.43 (0.73, 2.83) | 4.12 (1.52, 11.13) | 0.005 | ||||||
| rs1008562 (GG) | CXCR1 | 2q35 | 211 (27.9%) | 1.17 (0.89, 1.53) | Smoking | Non | 348 (46.2%) | 1.04 (0.68, 1.60) | Ref | |
| <20 PY | 160 (21.2%) | 0.88 (0.44, 1.75) | 0.96 (0.46, 1.98) | 0.905 | ||||||
| ≥20 PY | 245 (32.5%) | 1.88 (1.20, 2.95) | 2.05 (1.12, 3.76) | 0.019 | ||||||
| rs7656411 (GG) | TLR2 | 4q31.3 | 61 (8.1%) | 0.83 (0.48, 1.44) | Protein e | Low | 244 (32.3%) | 0.13 (0.02, 0.98) | Ref | |
| High | 512 (67.7%) | 1.33 (0.74, 2.38) | 8.69 (1.09, 69.12) | 0.041 | ||||||
| rs224082 (GA or AA) | EGR2 | 10q21.3 | 455 (60.2%) | 0.72 (0.56, 0.92) | Protein e | Low | 244 (32.3%) | 0.39 (0.25, 0.62) | Ref | |
| High | 512 (67.7%) | 0.93 (0.68,1.23) | 2.41 (1.40, 4.15) | 0.002 | ||||||
| rs17151957 (AA) | EGFR | 7p11.2 | 41 (6.5%) | 1. 82 (1.16, 2.88) | Protein e | Low | 244 (32.3%) | 0.54 (0.19, 1.53) | Ref | |
| High | 512 (67.7%) | 3.37 (1.95, 5.82) | 5.84 (1.80, 18.94) | 0.003 |
Abbreviations: GST, Gene-Specific Tree; Chr., Chromosome; Env., Environmental; PY, pack-years; HR, hazard ratio; CI, confidence interval. a Gene hazard ratios were adjusted for age, sex, race, study center, pathway tree, baseline hazard stratified by cancer stage; b N (%) frequency of the environmental variable within subjects with the GST; c HRINT: Interaction hazards ratio; d PINT: Interaction p-value; e Animal/Vegetable Protein Ratio.