Table 3.

Geometric (arithmetic) mean counts of live Ixodes ricinus and Rhipicephalus sanguineus ticks and dead, attached, engorged ticks in Study 1

Tick species	Day	Untreated control		Lotilaner			Comparison
		Mean	Range	Mean	Range	Efficacy (%)
Ixodes ricinus	2	18.3 (18.6)	14–26	0.7 (1.0)	0–2a	96.0 (94.6)	t (14) = 11.1, P < 0.0001
	9	24.5 (24.8)	20–28	0.6 (0.8)	0–2	97.7 (97.0)	t (14) = 15.1, P < 0.0001
	16	22.9 (23.6)	13–32	0.5 (0.8)	0–3	97.9 (96.8)	t (14) = 12.3, P < 0.0001
	23	23.6 (25.1)	11–33	0.6 (0.9)	0–2	97.3 (96.5)	t (14) = 11.3, P < 0.0001
	30	24.0 (24.6)	16–35	1.2 (1.6)	0–4	95.1 (93.4)	t (14) = 9.4, P < 0.0001
	37	24.2 (25.1)	12–35	0.7 (1.0)	0–3	97.1 (96.0)	t (14) = 11.2, P < 0.0001
Rhipicephalus sanguineus	2	25.0 (26.8)	9–40	0.1 (0.3)	0–2b	99.4 (99.1)	t (14) = 15.2, P < 0.0001
	9	29.7 (30.5)	18–39	0.0 (0.0)	0–0	100 (100)	t (14) = 37.6, P < 0.0001
	16	27.4 (28.6)	15–37	0.0 (0.0)	0–0	100 (100)	t (14) = 28.7, P < 0.0001
	23	31.4 (32.3)	21–48	0.0 (0.0)	0–0	100 (100)	t (14) = 40.8, P < 0.0001
	30	31.8 (32.6)	19–43	0.1 (0.1)	0–1	99.7 (99.6)	t (14) = 27.6, P < 0.0001
	37	29.8 (30.8)	17–41	0.1 (0.1)	0–1	99.7 (99.6)	t (14) = 25.4, P < 0.0001

^a48 h post-treatment live or dead engorged ticks were found on a single; this dog had two dead, engorged R. sanguinueus

^b48 h post-treatment four dogs were infested, each with two dead engorged I ricinus