Figure 2.

Photomicrographs of representative cases of fascin-/BRMS1+ and fascin+/BRMS1- breast cancers. (a) In contrast to stromal endothelial cells, which are normal internal controls, no fascin staining is observed in tumor cells. BRMS1 is stained in both nucleus and cytoplasm, but nuclear staining intensity is stronger than cytoplasm in this case. (b) Strong cytoplasmic fascin staining is observed in tumor cells, whereas BRMS1 is almost completely disappeared in the nucleus and is stained very faintly only in the cytoplasm