Table 1.
Correlations between fascin expression and clinicopathological features
| Parameter | Number | Fascin Negative | Fascin Positive | p-value | |
|---|---|---|---|---|---|
| n=150 | n=33 | ||||
| Age | <50 | 114 (62.3) | 91 (60.7) | 23 (69.7) | 0.428 |
| ≥50 | 69 (37.7) | 59 (39.3) | 10 (30.3) | ||
| Tumor stage | pT1 | 89 (48.6) | 72 (48.0) | 17 (51.5) | 0. 848 |
| pT2-3 | 94 (51.4) | 78 (52.0) | 16 (48.5) | ||
| Nodal stage | pN0 | 100 (54.6) | 74 (49.3) | 26 (78.8) | 0. 003 |
| pN1-3 | 83 (45.4) | 76 (50.7) | 7 (21.2) | ||
| AJCC stage | I | 148 (80.9) | 118 (79.4) | 30 (90.9) | 0.142 |
| II-III | 35 (19.1) | 32 (21.3) | 3 (9.1) | ||
| Histologic grade | 1 | 26 (14.2) | 26 (17.3) | 0 (0.0) | 0.005 |
| 2/3 | 157 (85.8) | 124 (82.7) | 33 (100.0) | ||
| Nuclear grade | 1 | 73 (39.9) | 68 (45.3) | 5 (15.2) | 0.001 |
| 2/3 | 110 (60.1) | 82 (54.7) | 28 (84.8) | ||
| Lymphovasculr invasion | Absent | 79 (43.2) | 60 (40.0) | 19 (57.6) | 0.081 |
| Present | 104 (56.8) | 90 (60.0) | 14 (42.4) | ||
| ER | Positive | 117 (63.9) | 114 (76.0) | 3 (9.1) | < 0.001 |
| Negative | 66 (36.1) | 36 (24.0) | 30 (90.9) | ||
| PR | Positive | 94 (51.4) | 91 (60.7) | 3 (9.1) | <0.001 |
| Negative | 89 (48.6) | 59 (39.3) | 30 (90.9) | ||
| HER2 | Negative | 143 (78.1) | 112 (74.7) | 31 (93.9) | 0.018 |
| Positive | 40 (21.9) | 38 (25.3) | 2 (6.1) | ||
| Intrinsic subtype | Luminal A | 101 (55.2) | 98 (65.3) | 3 (9.1) | <0.001 |
| Luminal B | 18 (9.8) | 18 (12.0) | 0 (0.0) | ||
| HER2 | 22 (12.0) | 20 (13.3) | 2 (6.1) | ||
| Triple-negative | 42 (23.0) | 14 (9.3) | 28 (84.8) | ||
| Tumor recurrence | Yes | 36 (19.7) | 28 (18.7) | 8 (24.2) | 0.473 |
| Patients death | Yes | 26 (14.2) | 20 (13.3) | 6 (18.0) | 0.581 |