Table 3.

Univariate and multivariate analyses of disease-free and overall survival

Parameters	Disease free survival			Overall survival
	Univariate	Multivariate		Univariate	Multivariate
	p-value	HR (95% CI)	p-value	p-value	HR (95% CI)	p-value
Analysis in all patients (n = 183)
Age (<50 vs. ≥50)	0.802			0.249
T stage (pT1 vs. pT2-3)	0.098			0.003	2.047 (0.759-5.520)	0.157
N stage (pN0 vs. pN1-3)	0.005	1.811 (0.833-4.201)	0.020	0.004	1.613 (0.563-4.619)	0.373
AJCC stage (I vs. II-III)	0.002	2.854 (1.212-4.812)	0.025	< 0.001	3.159 (1.460-6.834)	0.003
Histologic grade (1 vs. 2-3)	0.006	1.332 (0.926-3.278)	0.186	0.027	1.533 (0.823-3.554)	0.974
Nuclear grade (1 vs. 2-3)	0.055			0.103
Intrinsic subtype (non-TNBC vs. TNBC)	0.074			0.589
Fascin (Negative vs. Positive)	0.317			0.345
BRMS1-nuc (Moderate/Strong vs. Negative/Weak)	0.988			0.415
BRMS1-cyt (Moderate/Strong vs. Negative/Weak)	0.043	1.875 (0.949-3.702)	0.070	0.145
BRMS1-H score (3-6 vs. 0-2)	0.769			0.492
Fascin-/BRMS1+ vs. Fascin+/BRMS1-	0.698			0.430
Analysis in node-negative patients (n = 117)
Age (<50 vs. ≥50)	0.463			0.335
T stage (pT1 vs. pT2-3)	0.258			0.048	5.622 (1.055-29.968)	0.043
Histologic grade (1 vs. 2-3)	0.050			0.155
Nuclear grade (1 vs. 2-3)	0.136			0.549
Intrinsic subtype (non-TNBC vs. TNBC)	0.125			0.028	2.030 (0.127-32.417)	0.617
Fascin (Negative vs. Positive)	0.005	5.583 (1.318-23.655)	0.020	0.031	5.869 (1.202-28.662)	0.029
BRMS1-nuc (Moderate/Strong vs. Negative/Weak)	0.121			0.145
BRMS1-cyt (Moderate/Strong vs. Negative/Weak)	0.470			0.619
BRMS1-H score (3-6 vs. 0-2)	0.321			0.717
Fascin-/BRMS1+ vs. Fascin+/BRMS1-	0.240			0.041	1.185 (0.151-9.294)	0.871

nuc nuclear, cyt cytoplasmic, HR hazard ratio, CI confidence interval