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Involvement of lncRNAs in the “adenoma-carcinoma sequence”, multi-step model of CRC pathogenesis. LncRNAs participate in many signaling pathways involved in the pathogenesis of CRC, including the activation of Wnt/β-catenin signaling pathway, activation of EGFR/IGF-IR signaling pathway (KRAS and PI3K pathways), activation of TGF-β)/Smad signaling pathway, suppression of the p53 signaling pathway, and activation of EMT program.
