Table 2.
The association between PD-L1 expression and the clinicopathological factors.
|
Variables N (%) |
1% Cutoff | 5% Cutoff | 10% Cutoff | 50% Cutoff | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PD-L1, N (%) | P* | PD-L1, N (%) | P* | PD-L1, N (%) | P* | PD-L1, N (%) | P* |
||||||
| Negative | Positive | Negative | Positive | Negative | Positive | Negative | Positive | ||||||
| Age (years) | |||||||||||||
| < 60 | 188 (51.6) | 87 (46.3) | 101 (54.7) | 0.482 | 114 (60.6) | 74 (39.4) | 0.396 | 126 (67.0) | 62 (33.0) | 0.822 | 147 (78.2) | 41 (21.8) | 0.833 |
| ≥ 60 | 176 (48.4) | 75 (42.6) | 101 (57.4) | 99 (56.3) | 77 (43.8) | 116 (65.9) | 60 (34.1) | 136 (77.3) | 40 (22.7) | ||||
| Gender | |||||||||||||
| Male | 228 (62.6) | 92 (40.4) | 136 (59.6) | 0.039 | 91 (66.9) | 45 (33.1) | 0.012 | 99 (72.8) | 37 (27.2) | 0.049 | 172 (75.4) | 56 (24.6) | 0.170 |
| Female | 136 (37.4) | 70 (51.5) | 66 (48.5) | 122 (53.5) | 106 (46.5) | 143 (62.7) | 85 (37.3) | 111 (81.6) | 25 (18.4) | ||||
| Smoking Index (SI) | |||||||||||||
| SI < 400 | 203 (55.8) | 121 (59.6) | 82 (40.4) | < 0.001 | 148 (72.9) | 55 (27.1) | < 0.001 | 159 (78.3) | 44 (21.7) | < 0.001 | 169 (83.3) | 34 (16.7) | 0.005 |
| SI ≥ 400 | 161 (44.2) | 41 (25.5) | 120 (74.5) | 65 (40.4) | 96 (59.6) | 83 (51.6) | 78 (48.4) | 114 (70.8) | 47 (29.2) | ||||
| Clinical stage | |||||||||||||
| I | 175 (48.1) | 83 (47.4) | 92 (52.6) | 0.529 | 108 (61.7) | 67 (38.3) | 0.469 | 123 (70.3) | 52 (29.7) | 0.328 | 143 (81.7) | 32 (18.3) | 0.180 |
| II | 72 (19.8) | 29 (40.3) | 43 (59.7) | 41 (56.9) | 31 (43.1) | 46 (63.9) | 26 (36.1) | 55 (76.4) | 17 (23.6) | ||||
| IIIA | 117 (32.1) | 50 (42.7) | 67 (57.3) | 64 (54.7) | 53 (45.3) | 73 (62.4) | 44 (37.6) | 85 (72.6) | 32 (27.4) | ||||
| Tumor size | |||||||||||||
| ≤ 3 cm | 167 (45.9) | 75 (43.4) | 98 (56.6) | 0.674 | 109 (63.0) | 64 (37.0) | 0.098 | 121 (69.9) | 52 (30.1) | 0.183 | 135 (80.8) | 32 (19.2) | 0.192 |
| > 3 cm | 197 (54.1) | 87 (45.5) | 104 (54.5) | 104 (54.5) | 87 (45.5) | 121 (63.4) | 70 (36.6) | 148 (75.1) | 49 (24.7) | ||||
| Regional LN metastasis | |||||||||||||
| No | 204 (56.0) | 94 (46.1) | 110 (53.9) | 0.495 | 125 (61.3) | 79 (38.7) | 0.228 | 142 (69.6) | 62 (30.4) | 0.154 | 168 (82.4) | 36 (17.6) | 0.017 |
| Yes | 160 (44.0) | 68 (42.5) | 92 (57.5) | 88 (55.0) | 72 (45.0) | 100 (62.5) | 60 (37.5) | 115 (71.9) | 45 (28.1) | ||||
| Histology | |||||||||||||
| AD | 206 (56.6) | 94 (45.6) | 112 (54.4) | 0.622 | 127 (61.7) | 79 (38.3) | 0.166 | 145 (70.4) | 61 (29.6) | 0.072 | 166 (60) | 40 (19.4) | 0.138 |
| SCC | 158 (43.4) | 68 (43.0) | 90 (57.0) | 86 (54.4) | 72 (45.6) | 97 (61.4) | 61 (38.6) | 117 (74.1) | 41 (25.9) | ||||
| EGFR mutation | |||||||||||||
| No | 300 (82.4) | 132 (44.0) | 168 (56.0) | 0.674 | 174 (58.0) | 126 (42.0) | 0.665 | 200(66.7) | 100 (33.3) | 0.873 | 232 (77.3) | 68 (22.7) | 0.681 |
| Yes | 64 (17.6) | 30 (46.9) | 34 (53.1) | 39 (60.9) | 25 (39.1) | 42 (65.6) | 22 (34.4) | 51 (79.7) | 13 (20.3) | ||||
| NSE | |||||||||||||
| ≤15.2 ng/ml | 249 (68.4) | 112 (45.0) | 137 (55.0) | 0.789 | 174 (59.0) | 102 (41.0) | 0.767 | 167 (67.1) | 82 (32.9) | 0.728 | 196 (78.7) | 53 (21.3) | 0.514 |
| >15.2 ng/ml | 115 (31.6) | 50 (43.5) | 65 (56.5) | 66 (57.4) | 49 (42.6) | 75 (65.2) | 40 (34.8) | 87 (75.7) | 28 (24.3) | ||||
| CEA | |||||||||||||
| ≤ 5.0 ng/ml | 238 (65.4) | 104 (43.7) | 134 (56.3) | 0.670 | 135 (56.7) | 103 (43.3) | 0.340 | 155 (65.1) | 83 (34.9) | 0.451 | 187 (78.6) | 51 (21.4) | 0.603 |
| > 5.0 ng/ml | 126 (34.6) | 58 (46.0) | 68 (54.0) | 78 (61.9) | 48 (38.1) | 87 (69.0) | 39 (31.0) | 96 (76.2) | 30 (23.8) | ||||
| Cyfra21-1 | |||||||||||||
| ≤ 3.3 ng/ml | 195 (53.6) | 84 (43.1) | 111 (56.9) | 0.556 | 109 (55.9) | 86 (44.1) | 0.276 | 128 (65.6) | 67 (34.4) | 0.715 | 152 (77.9) | 43 (22.1) | 0.921 |
| > 3.3 ng/ml | 169 (46.4) | 78 (46.2) | 91 (53.8) | 104 (61.5) | 65 (38.5) | 114 (67.5) | 55 (32.5) | 131 (77.5) | 38 (22.5) | ||||
| SCCA | |||||||||||||
| ≤ 1.5 ng/ml | 283 (77.7) | 131 (46.3) | 152 (53.7) | 0.200 | 177 (62.5) | 106 (37.5) | 0.004 | 198 (70.0) | 85 (30.0) | 0.009 | 231 (81.6) | 52 (18.4) | 0.001 |
| > 1.5 ng/ml | 81 (22.3) | 31 (38.3) | 50 (61.7) | 36 (44.4) | 45 (55.6) | 44 (54.3) | 37 (45.7) | 52 (64.2) | 29 (35.8) | ||||
LN: lymph node. AD: adenocarcinoma. SCC: squamous cell carcinoma. SI: smoking index = (number of cigarettes per day) × (duration in years). *P values < 0.05 in bold.