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. 2017 Jul 20;6(10):e1353856. doi: 10.1080/2162402X.2017.1353856

Figure 6.

Figure 6.

ILT2 inhibits T cell proliferation in CLL and healthy donors. (A) IL-2-stimulated (50 U/mL) or unstimulated PBMCs obtained from 12 CLL patients and 7 healthy donors were stained with CFSE and cultured in the presence of anti-ILT2 blocking antibody (10 μg/ml) or irrelevant IgG1 for 7 days, and the proliferation of different cell subsets was analyzed by flow cytometry. Histograms show the flow cytometry profiles corresponding to CFSE expression in T cells, CD8 T cells, CD4 T cells and leukemic cells of a representative CLL patient. (B-E) Comparison of the percentage of proliferating T cells (B), CD8 T cells (C), CD4 T cells (D) and B cells (E) from patients and donors between the different experimental conditions analyzed are shown. Bars represent the mean ± SEM from samples analyzed.