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. 2017 Jul 20;6(10):e1353856. doi: 10.1080/2162402X.2017.1353856

Figure 8.

Figure 8.

ILT2 blockade increases IL-2 levels and reduces IFN-γ production by T cells in CLL patients. (A) PBMCs from 15 CLL patients and 6 donors were cultured in the presence of anti-ILT2 blocking antibody or irrelevant IgG1 for 48 hours, and the intracytoplasmic expression of IL-2 and IFN-γ was analyzed in T and B cells by flow cytometry. Dot plots show the level of IL-2 expression in CD4 T cells and IFN-γ expression in CD8 T cells from a CLL patient. The mean of percentage ± SEM of intracytoplasmic levels of IL-2 in patients (B) and healthy donors (C) is shown. The intracytoplasmic expression of IFN-γ in patients (D) and healthy donors (E) is shown.