Table 1.
Clinical characteristics of CLL patients.
| Patients |
||
|---|---|---|
| No. | % | |
| Age (years) | 68 (Mean) | |
| Sex | ||
| Male | 28 | 53.8 |
| Female | 24 | 46.2 |
| Binnet stage | ||
| A | 44 | 84.6 |
| B | 5 | 9.6 |
| C | 3 | 5.8 |
| Rai stage | ||
| 0 | 30 | 57.7 |
| I | 11 | 21.2 |
| II | 7 | 13.5 |
| III-IV | 4 | 7.6 |
| ECOG performance status | ||
| 0 | 40 | 70.9 |
| 1 | 7 | 13.5 |
| 2 | 5 | 9.6 |
| Cytogenetic abnormalities (FISH) (n = 48) | ||
| del(17p) | 6 | 12.5 |
| del(11q) | 5 | 9.6 |
| del(13q) | 36 | 75 |
| Trisomy 12 | 7 | 13.5 |
| Metaphase karyotype | ||
| Complex | 6 | 12.8 |
| Single abnormality | 13 | 27.7 |
| Diploid | 17 | 36.2 |
| IGHV mutation status (n = 44) | ||
| Unmutated | 11 | 21.2 |
| Mutated | 30 | 57.7 |
| Discordant | 3 | 5.8 |
| CD38 expression (n = 49) | ||
| Positive (≥ 30%) | 10 | 19.2 |
| ZAP-70 (n = 37) | ||
| Flow positive (≥ 20%) | 9 | 31.7 |
| Progressive disease | 30 | 57.7 |
| Stable disease | 22 | 42.3 |