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. 2017 Oct 26;16:1536012117734485. doi: 10.1177/1536012117734485

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Metabolite correction of palmitate at 5 different time points during a 50-minute dynamic PET scan. A, The amount of radioactivity present as FFAs measured with the SPE method. A repeated measures ANOVA showed significantly lower activity in the FFA fraction in hyperinsulinemic patients (mixed model repeated measures ANOVA [group] P <.0001, [group vs time interaction] P < .0001). There was no difference in time-activity curves between healthy controls and patients with T2D (mixed model repeated measures ANOVA [group] P = .14, [group vs time interaction] P = .39). B, [¹¹C] activity in complex lipids (mainly TGs) measured by the SPE method. Significantly more activity was present in this fraction during hyperinsulinemia (ANOVA [group] P = .02), whereas no difference was detected between controls and T2D (ANOVA [group] P = .17). C, Radioactivity detected in the CO₂ fraction, with significantly more in patients during hyperinsulinemia (ANOVA [group] P = .003) and no difference between T2D and controls (ANOVA [group] P = .72). Error bars represent ± standard errors. ANOVA indicates analysis of variance; FFAs, free fatty acids; PET, positron emission tomography; SPE, solid-phase extraction; T2D, type 2 diabetes; TG, triglyceride.