Table 1.
Baseline Characteristics and Test Result of Patients Categorized on the Basis of the G6PD:GR Ratio.
| Females |
||||
|---|---|---|---|---|
| Ratio <0.46 mean (SD) |
Ratio 0.46–0.9 mean (SD) |
Ratio >0.9 mean (SD) |
Cutoff Points for Normal Values | |
| Number | 3 | 62 | 10 | |
| Age (years) | 58 (12) | 41 (27) | 46 (25) | |
| G6PD activity (IU/g Hb) | 2.23 (0.38) | 4.39 (0.73) | 4.80 (0.49) | >3.8 IU/g Hb |
| Inhibited GR activity in the presence of chromate (IU/g Hb) | 4.30 (0.61) | 1.74 (1.37) | 0.71 (0.28) | <1.7 IU/g Hb |
| G6PD:GR ratio | 0.42 (0.04) | 0.74 (0.12) | 1.07 (0.20) | ≥0.9 |
| Cytofluorometry G6PD-negative cells (%) | 68.2 (10.9) | 15.2 (18.7) | 1.5 (1.6) | <10.15 |
A ratio >0.9 indicates no G6PD deficiency, a ratio <0.46 indicates G6PD deficiency. Females with a ratio between 0.46 and 0.9 are suspected to have heterozygous G6PD deficiency. In the last column, the reference values for spectrophotometry, spectrophotometry with chromate inhibition, and cytofluorometry are given. Abbreviations: G6PD, glucose-6-phosphate dehydrogenase; IU g/Hb, international units per gram hemoglobin; GR, glutathione reductase.