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. 2016 Jul 11;16(5):546–558. doi: 10.1177/1533034616657976

Figure 2.

Figure 2.

Effects of amarogentin on liver cell proliferation. The inhibitory effect of amarogentin was more obvious in cancer cells than in normal cells. A, The linear relationships of the LO2 cell concentration with the survival rate at 24, 48, and 72 hours were y24h = 0.987 − 0.0028x (95% confidence interval [CI]: 0.969-1.006), y48h = 0.923 − 0.003x (95% CI: 0.903-0.943), and y72h = 0.916 − 0.0036x (95% CI: 0.871-0.962). The half-maximal inhibitory concentration (IC50) values of amarogentin for the LO2 cells at 24, 48, and 72 hours were 173.93, 141, and 115.5 µg/mL, respectively. B, The linear relationships of the HepG2 cell concentration with the survival rate at 24, 48, and 72 hours were y24h = 0.912 − 0.0031x (95% CI: 0.894-0.931), y48h = 0.864 − 0.0033x (95% CI: 0.836-0.893), and y72h = 0.783 − 0.0036x (95% CI: 0.739-0.827). The IC50 values for the HepG2 cells at 24, 48, and 72 hours were 132.90, 110.30, and 78.61 µg/mL, respectively. C, The linear relationships of the SMMC-7721 cell concentration with the survival rate at 24, 48, and 72 hours were y24h = 0.971 − 0.0026x (95% CI: 0.946-0.995), y48h = 0.958 − 0.0037x (95% CI: 0.934-0.982), and y72h = 0.883 − 0.0039x (95% CI: 0.780-0.896). The IC50 values for the SMMC-7721 cells at 24, 48, and 72 hours were 181.15, 123.78, and 86.67 µg/mL, respectively.