Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(A) Optimized ligand of the Ras switch II pocket elaborated with a set of electrophiles. (B) Aziridine and stabilized diazo groups preferentially react with carboxylates at pH 6. (C) Many of the electrophiles covalently label K-Ras G12C. (D) Compound 3 modestly labels G12D and G12S at pH 5.5. (E) DSF suggests that 3 and 4 may bind Ras differently.
