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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Biochemistry. 2017 Jun 16;56(25):3178–3183. doi: 10.1021/acs.biochem.7b00271

Figure 3.

Figure 3

(A) Piperazine linker that was replaced with an exocyclic amine and elaborated with several electrophiles. (B) Compounds 11–13 and 16–19 label K-Ras G12C. (C) DSF shows a relationship between stabilization and the position of the electrophilic atom. Compounds with an ambiguous site of labeling are not shown. (D) Despite equivalent stabilization, 1 labels K-Ras G12C more quickly than 11 does. (E) For the chloroacetamides, 6 labels much more rapidly than the equivalently stabilizing 13 does.