Skip to main content
. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Eur J Cancer. 2017 Jul 20;83:132–141. doi: 10.1016/j.ejca.2017.06.024

Figure 4. ABCC4 knockdown slows the growth of xenografted human neuroblastoma cells.

Figure 4

(A, B) Induction of ABCC4 knockdown in established BE(2)-C tumors (doxycycline treatment commenced 7 days post-engraftment) extends survival (P = 0.008 for ABCC4.6, P = 0.182 for ABCC4.7, n = 9–10/group). (C) Tumor growth in individual mice for ABCC4.6 with and without doxycycline. (D) Doxycycline-induced knockdown of ABCC4 is maintained in xenografted tumors to the experimental end-point for both ABCC4.6 and ABCC4.7. GAPDH is shown as a loading control and a different tumor sample is shown in each lane. (E) Histological appearance of representative xenografts from each cohort (H&E staining). Coagulative necrosis, where cell outlines are preserved (*), is seen in all treatment groups. Magnification: 400x.