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. Author manuscript; available in PMC: 2018 Oct 17.
Published in final edited form as: Immunity. 2017 Oct 17;47(4):635–647.e6. doi: 10.1016/j.immuni.2017.09.011

Figure 3. Mutations within the cRHIM Motif Disrupt the Formation of Amyloidal Aggregates.

Figure 3

(A and B) SDD-AGE profiles of wild-type (WT), deletion mutant, and alanine substitution mutants of PGPR-LC201-242 (A) and PGRP-LE80-127 (B). ΔcRHIM represents deletion of amino acids 209–225 in PGRP-LC201-242 and of amino acids 98–113 in PGRP- LE80-127. RIPK1/3-RHIM complex was loaded as a positive control.

(C) Schematic representation of recombinant IMD31-273, deletion mutants, and their SDD-AGE profiles.