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. 2017 Oct 3;3:17035. doi: 10.1038/celldisc.2017.35

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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YY2 K247 methylation is involved in YY2-regulated cell proliferation and tumor growth. (a) HeLa cells were infected with control lentiviral vector or vectors expressing YY2 (wt) or YY2 (K247R), followed by cell number counting every 2 days. Significance test for the change of cell number between CTL and YY2 (wt), or YY (wt) and YY2 (K247R) on days 2 (inset), 4 (inset) and 6 were shown as indicated (±s.e.m., *P<0.05, **P<0.01). (b) HeLa cells as described in a were subjected to IB analysis using antibodies as indicated. (c) HeLa cells as described in a were injected into female athymic Nu/Nu mice as shown. (d) Mice as described in c were killed 3 weeks after subcutaneous injection, and tumors were then excised, photographed and weighed. (e) Significance test for the weight of tumors shown in d was performed.