Table 2.

Sensitivity analysis for treatment effect on mortality according to different cut-off points of prescribed dose and delivered dose

	Number of studies included	Pooled OR	Lower limit	Upper limit	Z value	p Value
Prescribed dose
(A) 90-day mortality
50 mL/kg/h	2	0.97	0.66	1.43	−0.16	0.88
40 mL/kg/h	3	0.83	0.50	1.38	−0.71	0.48
30 mL/kg/h	2	0.73	0.39	1.38	−0.97	0.33
(B) ICU mortality
50 mL/kg/h	1	1.20	0.58	2.47	0.50	0.62
40 mL/kg/h	2	1.04	0.85	1.28	0.37	0.72
30 mL/kg/h	3	1.13	0.92	1.38	1.18	0.24
(C) Hospital mortality
50 mL/kg/h	2	1.11	0.75	1.65	0.53	0.60
40 mL/kg/h	2	1.02	0.71	1.45	0.08	0.94
30 mL/kg/h	2	0.98	0.73	1.31	−0.15	0.88
Delivered dose
(A) 90-day mortality
50 mL/kg/h	2	0.97	0.66	1.43	−0.16	0.88
40 mL/kg/h	1	1.24	0.63	2.43	0.63	0.53
30 mL/kg/h*	1	1.00	0.81	1.23	−0.03	0.97
(B) ICU mortality
50 mL/kg/h	1	1.20	0.58	2.47	0.50	0.62
40 mL/kg/h	2	1.39	0.96	2.00	1.75	0.08
30 mL/kg/h	2	1.16	0.84	1.62	0.90	0.37
(C) Hospital mortality
50 mL/kg/h	1	0.99	0.61	1.61	−0.03	0.98
40 mL/kg/h	1	1.39	0.71	2.74	0.96	0.34
30 mL/kg/h	1	0.91	0.65	1.29	−0.52	0.60

*Ronco et al¹⁴ did not provide information on delivered dose of continuous renal replacement therapy and therefore was excluded.

ICU, intensive care unit.