Table 1.

Inclusion and exclusion criteria

Inclusion	Exclusion
Expected to require more than 48 hours of invasive mechanical ventilation	Pre-existing condition that is likely to impair mobility/mobility assessment (ie, significant neurological, musculoskeletal, cognitive or mental health disorder)
Able to provide consent or have a family member consent on their behalf	Neuromuscular disorder or acute primary brain lesion (ie, traumatic brain injury, intracranial haemorrhage, stroke or hypoxic brain injury)
Enrolled into the study within 96 hours of ICU admission	Injuries precluding cycle ergometry (ie, spinal/pelvic/lower limb orthopaedic injuries/open abdominal wound)
Expected to remain in ICU for more than 48 hours following study enrolment	Obesity >135 kg (MOTOmed Letto 2 maximum rated weight capacity)
	Uncontrolled seizures or status epilepticus
	Dire prognosis (ie, unlikely to survive the current admission)
	Pregnancy
	Children and/or young people (ie, <18 years)

ICU, intensive care unit.