Table 3.

CYCLIST summary of time points of assessments

	Baseline	Day 3	Day 7	Day 10	ICU discharge	1 week post ICU discharge*	3, 6 months’ post ICU-admission
Severity of illness
APACHE III	✓
SOFA	✓	✓	✓	✓	✓
Muscle morphology
Quadriceps ultrasonography	✓	✓	✓	✓		✓
Strength measures
MRC sum score					✓	✓
Handgrip dynamometry					✓	✓
Physical function measures
ICU mobility scale					✓
FSS-ICU					✓
Functional milestones	✓	✓	✓	✓	✓	✓
6-MWT						✓
Cognition
CAM-ICU	✓	✓	✓	✓	✓
Quality of life
EQ-5D-5L				✓			✓
Acceptability of intervention
Participant acceptability				✓†
Patient outcomes
ICU length of stay					✓
Hospital length of stay						✓‡
Acute discharge destination						✓‡
Mortality					✓	✓‡	✓

*1-week post-ICU discharge or at acute hospital discharge if sooner.

†At completion of in-bed cycle ergometry sessions.

‡Measured at acute hospital discharge.

6-MWT, 6 min walk test; APACHE, Acute Physiology and Chronic Health Evaluation; CAM-ICU, Confusion Assessment Method for the Intensive Care Unit; CYCLIST, Critical Care Cycling Study; EQ-5D-5L, EuroQol Five Dimensions questionnaire Five Levels scale.; FSS-ICU, Functional Status Score for the Intensive Care Unit; ICU, intensive care unit; MRC, Medical Research Council; SOFA, Sequential Organ Failure Assessment score.