Table 3. Baseline Characteristics of the Study Population, According to Number of Variants of Interest.
| Characteristic | 0 VOIs (N=72) | 1 VOIs (N=74) | ≥2 VOIs (N=28) | P Value |
|---|---|---|---|---|
| Age – yr | 26±15 | 26±16 | 28±18 | 0.81 |
| Male sex — no. (%) | 50 (69) | 54 (73) | 19 (68) | 0.84 |
| Atrial fibrillation – no. (%) | 4 (6) | 6 (8) | 5 (18) | 0.14 |
|
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| LV volume parameters | ||||
|
| ||||
| LVEF <50% – no. (%) | 15 (21) | 21 (28) | 14 (50) | 0.02 |
| LVEF – % | 53±12 | 50±15 | 43±19 | 0.01 |
| LVEDVI – ml/m2 | 106±46 | 112±45 | 124±59 | 0.27 |
| LVESVI – ml/m2 | 54±42 | 61±46 | 80±61 | 0.05 |
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| Distribution of non-compaction | ||||
|
| ||||
| Number of affected segments | 7.3±2.8 | 8.0±3.0 | 8.9±2.8 | 0.03 |
| Inter-ventricular septum affected – no. (%) | 15 (21) | 15 (20) | 10 (36) | 0.22 |
| Basal segments affected – no. (%) | 12 (17) | 20 (27) | 11 (39) | 0.05 |
| NC/C ratio | 2.2±0.7 | 2.5±0.8 | 2.9±1.0 | <0.001 |
| Fulfilled CMR criteria for LVNC – no. (%) | 22 (31) | 46 (62) | 22 (79) | <0.001 |
| Phenotype: LVNC+ DCM+ | 5 (7) | 14 (19) | 12 (43) | <0.001 |
| Phenotype: LVNC+ DCM- | 17 (24) | 32 (43) | 10 (36) | 0.04 |
| Presence of LGE – no. (%) | 3 (4) | 13 (18) | 4 (14) | 0.04 |
P values are for the overall comparison among the groups. Multiple family members excluded.
Abbreviations as in Table 1.