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. 2017 Oct 1;144(19):3405–3416. doi: 10.1242/dev.139063

Fig. 3.

Fig. 3.

Decomposition of the PAR network into two smaller, mutually inhibitory subcircuits. (A) The PAR-3/PAR-1 subcircuit involves mutual antagonism between PAR-3 oligomers and PAR-1. PAR-3 promotes local association of PAR-6/PKC-3 with active CDC-42; PKC-3 phosphorylates and inhibits membrane association of PAR-1; PAR-1 phosphorylates PAR-3 and inhibits membrane association and/or oligomerization. (B) The CDC-42/CHIN-1 subcircuit involves mutual antagonism between active CDC-42 and clustered CHIN-1. Active CDC-42 binds PAR-6/PKC-3 in the presence of PAR-3; PAR-6/PKC-3 inhibits local growth and accumulation of CHIN-1 clusters; CHIN-1 inactivates CDC-42.