Fig. 8.

Restoring normal synaptic Wg levels alleviates Notum null phenotypes. (A) Representative NMJ images co-labeled for HRP (red) and Wg (green) in w¹¹¹⁸, Notum^KO and the mutant with removal of one copy of wg (wg^1-17/+; Notum^KO/Notum^KO). (B) The same genotypes co-labeled for HRP (green) and DLG (red). (C) Quantification of extracellular Wg ligand level (C) and bouton number (D) in above three genotypes. (E) Coordinated movement rollover reaction time quantification for the three genotypes. *P≤0.05, **P≤0.01, ***P≤0.001; n.s., not significant.