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. 2017 Oct 1;144(19):3465–3474. doi: 10.1242/dev.152520

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Combined effect of Notch and IDs can drive NSC differentiation, proliferation and quiescence. (A) Expression level of Hes mRNA for different levels of ID expression in the presence of constant Notch activity (I=500 molecules). (B) Expression level of Hes mRNA relative to different levels of ID expression and Notch activity. (C) Expression level of proneural factor mRNAs for different values of ID expression in the presence of constant Notch activity. (D) Levels of proneural factor activity (protein level) for different levels of Notch activity and ID expression. IDs potentiate the effect of Notch signaling by releasing Hes auto-repression and can act in concert with Notch, forming a three-way switch that segregates NSCs into quiescent (qNSC) (high IDs), proliferative/active (aNSC) (low IDs, high Notch/Hes) or differentiated (Diff) (low IDs, low Notch/Hes). The oscillatory region is presented in Fig. S2.