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. 2017 Oct 1;144(19):3475–3486. doi: 10.1242/dev.153965

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 9. — Model to explain meiosis I-specific SAC arrest following DNA damage. Possible mechanisms by which the SAC/DDR checkpoint functions specifically in meiosis I. (A) A meiosis I-specific protein could transduce a signal from sites of DNA damage in close proximity to the kinetochore to allow SAC signalling on the kinetochore; alternatively, this might happen due to the unique proximity of the two sister kinetochores in meiosis I. (B) The large volume of chromatin under tension during meiosis I might make the bivalent more sensitive to DNA damage compared with meiosis II or to mitosis.