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. 2017 Nov 1;12(11):e0186275. doi: 10.1371/journal.pone.0186275

Fig 5. Schema of correlative associations between GGAA motifs in EWS/FLI-bound microsatellites for gene activation and repression.

Fig 5

Schematic illustrating EWS/FLI responsiveness at given loci across the genome. (A) Promoter-like (close-range) GGAA-microsatellites positively correlate with EWS/FLI binding and activation of genes in a length dependent manner. (B) Enhancer-like (long-range) GGAA-microsatellites positively correlate with EWS/FLI binding but correlation with transcriptional regulation is only minimal for activated genes. (C) Promoter-like GGAA-microsatellites display no correlation with EWS/FLI binding and transcriptional repression. (D) Enhancer-like GGAA-microsatellites positively correlate with EWS/FLI binding; however, they do not confer gene expression.