Table 3.
Annual Change in eGFR (ml/min/1.73 m2) by Tertiles of 25(OH)D (n = 273)
| White participants | Black participants | |||||||
|---|---|---|---|---|---|---|---|---|
| 25(OH)D range(ng/ml) | Tertile 1 1.5–18.5 | Tertile 2 18.6–27.5 | Tertile 3 27.6–53.9 | p | Tertile 1 1.0–10.2 | Tertile 2 10.5–16.6 | Tertile 3 16.7–48.0 | p |
| Model 1 | −0.79 (−1.51, −0.07) | −0.13 (−0.83, 0.58) | Reference | .03 | 0.35 (−1.21, 1.92) | 0.34 (−1.23, 1.92) | Reference | .66 |
| Model 2 | −0.80 (−1.54, −0.06) | −0.08 (−0.81, 0.64) | Reference | .03 | 0.59 (−0.96, 2.14) | 0.20 (−1.36, 1.77) | Reference | .44 |
| Model 3 | −0.82 (−1.56, −0.08) | −0.09 (−0.82, 0.64) | Reference | .03 | 0.60 (−0.96, 2.15) | 0.21 (−1.36, 1.78) | Reference | .46 |
| Annual change in eGFR estimated from Model 3 | −2.06 (−2.58, −1.53) | −1.34 (−1.84, −0.84) | −1.23 (−1.77, −0.68) | −1.64 (−2.70, −0.57) | −1.96 (−3.05, −0.87) | −2.24 (−3.37, −1.11) | ||
Model 1 covariates: age, center, cohort, and follow-up time. Model 2 covariates: Model 1 + baseline education below college, baseline income less than $20,000, longitudinal values of diabetes and hypertension status, and log transformed CD4 count and viral load. Model 3 covariates: Model 2 + baseline 1,25(OH)2D. Random effects: random intercept, which accounted for difference in baseline eGFR, and random slope, which accounts for individual differences in eGFR change patterns. p-Value was obtained using an interaction term between follow-up time in years and the tertile of 25(OH)D as an ordinal variable. Sample sizes were 187 for white participants and 86 for black participants in all models. Serum 25(OH)D ranges were based on seasonally adjusted values.