Table 4.
Annual Change in eGFR (ml/min/1.73 m2) by Tertiles of 1,25(OH)2D (n = 273)
| Range (pg/ml) | Tertile 1 5.9–40.2 | Tertile 2 40.3–51.3 | Tertile 3 51.4–96.9 | p |
|---|---|---|---|---|
| Difference in annual change in eGFR using tertile 3 as the reference | ||||
| White participants | ||||
| Model 1 | −0.22 (−0.95, 0.51) | 0.16 (−0.60, 0.89) | Reference | .51 |
| Model 2 | −0.20 (−0.95, 0.55) | 0.09 (−0.67, 0.85) | Reference | .56 |
| Black participants | ||||
| Model 1 | −1.17 (−2.80, 0.46) | −0.55 (−1.98, 0.88) | Reference | .15 |
| Model 2 | −1.39 (−2.99, 0.21) | −0.57 (−1.97, 0.84) | Reference | .09 |
| Overall | ||||
| Model 1 | −0.39 (−1.09, 0.30) | −0.22 (−0.90, 0.46) | Reference | .29 |
| Model 2 | −0.50 (−1.11, 0.10) | −0.31 (−0.89, 0.28) | Reference | .18 |
| Annual change in eGFR estimated from Model 2 | ||||
| White | −1.72 (−2.24, −1.20) | −1.43 (−1.96, −0.90) | −1.49 (−2.05, −0.93) | |
| Black | −2.71 (−3.96, −1.47) | −1.95 (−2.92, −0.97) | −1.35 (−2.38, −0.33) | |
| Overall | −1.76 (−2.21, −1.32) | −1.57 (−1.98, −1.16) | −1.26 (−1.68, −0.84) | |
Model 1 covariates: baseline age, center, cohort, and follow-up time. Model 2 covariates: Model 1+baseline education below college, baseline income less than $20,000, longitudinal values of diabetes and hypertension status, and log transformed CD4 count and viral load. Race was a covariate in the overall analysis combining whites and blacks. Random effects: random intercept, which accounted for difference in baseline eGFR, and random slope, which accounts for individual differences in eGFR change patterns. p-Value was obtained using an interaction term between follow-up time in years and the tertiles of 25(OH)D as an ordinal variable. Sample sizes were 187 for white participants and 86 for black participants in all models.