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. 2017 Nov 1;12(11):e0185666. doi: 10.1371/journal.pone.0185666

Table 4. Percent of individuals with antisera with HAI activity that recognized more, fewer, or similar number of strains in the panel post-vaccination compared to pre-challenge.

Year-Subtype ≤ 2* Similar ≥ 2* Year-Subtype ≤ 2 Similar ≥ 2
Age 2014-H1N1 2014-H3N2
18–34 18% 67% 15% 13% 87% 0%
35–49 32% 68% 0% 60% 37% 3%
50–64 44% 56% 0% 61% 36% 3%
65–85 42% 55% 2% 59% 40% 1%
2015-H1N1 2015-H3N2
18–34 13% 73% 15% 37% 47% 16%
35–49 26% 46% 22% 50% 48% 2%
50–64 37% 55% 8% 61% 34% 5%
65–85 39% 55% 6% 66% 28% 6%
2016-H1N1 2016-H3N2
18–34 33% 68% 0% 28% 72% 0%
35–49 59% 38% 3% 44% 56% 0%
50–64 35% 65% 0% 48% 52% 0%
65–85 35% 62% 3% 53% 47% 0%

*≥2 or more = Antisera detects 2 or more viruses post-vaccination compared to pre-vaccination in the HAI assay in the panel

Similar = Antisera detects 1 more, the same, or 1 fewer virus post-vaccination compared to pre-vaccination in the HAI assay in the panel post-vaccination

≤2 or fewer = Antisera detects 2 or fewer viruses post-vaccination compared to pre-vaccination in the HAI assay in the panel