Table 3. Diagnostic accuracy of clinical variables, inflammatory markers, and CT and comparisons of areas under curves.
| Markers | AUC (95% CI) | Cut-off | Sensitivity (95% CI) | Specificity (95% CI) | p-value |
|---|---|---|---|---|---|
| DNI | 0.902 (0.838–0.947) | > 0.7 | 94.2 (84.1–98.8) | 80 (69.6–88.1) | < 0.001 |
| Age | 0.739 (0.655–0.811) | - | 73.1 (59–84.4) | 73.8 (62.7–83) | 0.001 |
| Fever/chill | 0.584 (0.495–0.669) | - | 44.2 (30.5–58.7) | 72.5 (61.4–81.9) | < 0.001 |
| CRP | 0.673 (0.586–0.752) | > 9.45 | 59.6 (45.1–73) | 76.3 (65.4–85.1) | < 0.001 |
| Neutrophil | 0.619 (0.530–0.702) | 10460 | 53.9 (39.5–67.8) | 76.3 (65.4–85.1) | < 0.001 |
| NLR | 0.749 (0.666–0.820) | 9.158 | 55.8 (41.3–69.5) | 88.8 (79.7–94.7) | < 0.001 |
| CT | 0.943 (0.889–0.976) | - | 96.2 (86.8–99.5) | 92.5 (84.4–97.2) | - |
| CT+age | 0.969 (0.923–0.991) | - | 96.2 (86.8–99.5) | 93.8 (86–97.9) | 0.079 |
| CT+fever/chills | 0.943 (0.889–0.976) | - | 96.2 (86.8–99.5) | 92.5 (84.4–97.2) | 0.977 |
| CT+DNI | 0.981 (0.941–0.997) | - | 96.2 (86.8–99.5) | 92.5 (84.4–97.2) | 0.007 |
| CT+CRP | 0.968 (0.922–0.991) | - | 98.1 (89.7–100) | 91.3 (82.8–96.4) | 0.039 |
| CT+Neutrophil | 0.976 (0.933–0.995) | - | 100 (93.2–100) | 92.5 (84.4–97.2) | 0.019 |
| CT+NLR | 0.978 (0.936–0.996) | - | 98.1 (89.7–100) | 92.5 (84.4–97.2) | 0.023 |
CT: computed tomography, AUC: area under curve, CI: confidence interval, DNI: delta neutrophil index, CRP: C-reactive protein, NLR: neutrophil-to-lymphocyte ratio.