Table 5.
Response by initial dose cohort of lestaurtinib for patients on treatment for 3 months or longer
| Response | All Patients on Treatment for ≥3 Months N=16 |
Dose Cohort 80– 100 N=4 |
Dose Cohort 120 N=3 |
Dose Cohort 140 N=3 |
Dose Cohort 160 N=6 |
|
|---|---|---|---|---|---|---|
| Spleen | CR | 1 | 0 | 0 | 0 | 1 |
| PR | 10 | 3 | 2 | 1 | 4 | |
| NR | 5 | 1 | 1 | 2 | 1 | |
|
| ||||||
| Hemoglobin | Stable | 15 | 4 | 3 | 3 | 5 |
| Progression | 1 | 0 | 0 | 0 | 1 | |
|
| ||||||
| Platelet | CR | 3 | 0 | 1 | 0 | 2 |
| count | Stable or Minor Change | 13 | 4 | 2 | 3 | 4 |
|
| ||||||
| White Blood | CR | 3 | 1 | 0 | 0 | 2 |
| Cell count | Stable or Minor Change | 13 | 3 | 3 | 3 | 4 |
|
| ||||||
| Symptoms | Baseline Symptoms & Resolution | 3 | 0 | 1 | 1 | 1 |
| Baseline Symptoms & Incomplete Resolution/Stable | 7 | 4 | 1 | 0 | 2 | |
| No Baseline Symptoms & No Progression | 4 | 0 | 1 | 2 | 1 | |
| No Baseline Symptoms & Progression | 2 | 0 | 0 | 0 | 2 | |
|
| ||||||
| Global | CR | 0 | 0 | 0 | 0 | 0 |
| Response | Major Response | 0 | 0 | 0 | 0 | 0 |
| EUMNET | Moderate Response | 8 | 3 | 2 | 1 | 2 |
| Minor Response | 0 | 0 | 0 | 0 | 0 | |
| No Response | 8 | 1 | 1 | 2 | 4 | |
|
| ||||||
| Global | CR | 0 | 0 | 0 | 0 | 0 |
| Response | Major Response | 10 | 3 | 2 | 1 | 4 |
| Disregarding | Moderate Response | 0 | 0 | 0 | 0 | 0 |
| Symptoms | Minor Response | 0 | 0 | 0 | 0 | 0 |
| EUMNET | No Response | 6 | 1 | 1 | 2 | 2 |
|
| ||||||
| IWG | CR | 0 | 0 | 0 | 0 | 0 |
| Response | PR | 0 | 0 | 0 | 0 | 0 |
| Clinical Improvement | 7 | 1 | 1 | 0 | 5 | |
| Stable Disease | 8 | 3 | 2 | 2 | 1 | |
| Progressive Disease | 1 | 0 | 0 | 1 | 0 | |