Table 5.
Response | All Patients on Treatment for ≥3 Months N=16 |
Dose Cohort 80– 100 N=4 |
Dose Cohort 120 N=3 |
Dose Cohort 140 N=3 |
Dose Cohort 160 N=6 |
|
---|---|---|---|---|---|---|
Spleen | CR | 1 | 0 | 0 | 0 | 1 |
PR | 10 | 3 | 2 | 1 | 4 | |
NR | 5 | 1 | 1 | 2 | 1 | |
| ||||||
Hemoglobin | Stable | 15 | 4 | 3 | 3 | 5 |
Progression | 1 | 0 | 0 | 0 | 1 | |
| ||||||
Platelet | CR | 3 | 0 | 1 | 0 | 2 |
count | Stable or Minor Change | 13 | 4 | 2 | 3 | 4 |
| ||||||
White Blood | CR | 3 | 1 | 0 | 0 | 2 |
Cell count | Stable or Minor Change | 13 | 3 | 3 | 3 | 4 |
| ||||||
Symptoms | Baseline Symptoms & Resolution | 3 | 0 | 1 | 1 | 1 |
Baseline Symptoms & Incomplete Resolution/Stable | 7 | 4 | 1 | 0 | 2 | |
No Baseline Symptoms & No Progression | 4 | 0 | 1 | 2 | 1 | |
No Baseline Symptoms & Progression | 2 | 0 | 0 | 0 | 2 | |
| ||||||
Global | CR | 0 | 0 | 0 | 0 | 0 |
Response | Major Response | 0 | 0 | 0 | 0 | 0 |
EUMNET | Moderate Response | 8 | 3 | 2 | 1 | 2 |
Minor Response | 0 | 0 | 0 | 0 | 0 | |
No Response | 8 | 1 | 1 | 2 | 4 | |
| ||||||
Global | CR | 0 | 0 | 0 | 0 | 0 |
Response | Major Response | 10 | 3 | 2 | 1 | 4 |
Disregarding | Moderate Response | 0 | 0 | 0 | 0 | 0 |
Symptoms | Minor Response | 0 | 0 | 0 | 0 | 0 |
EUMNET | No Response | 6 | 1 | 1 | 2 | 2 |
| ||||||
IWG | CR | 0 | 0 | 0 | 0 | 0 |
Response | PR | 0 | 0 | 0 | 0 | 0 |
Clinical Improvement | 7 | 1 | 1 | 0 | 5 | |
Stable Disease | 8 | 3 | 2 | 2 | 1 | |
Progressive Disease | 1 | 0 | 0 | 1 | 0 |