CYD0692 inhibits HSC proliferation more potently than oridonin. LX-2 cells (A), HSC-T6 cells (C) and C3A hepatocytes (D) were treated with a series of concentrations of CYD0692 for 48 hours, and cell viability was determined using Alamar Blue assay. LX-2 cells were treated with 0.75 μM of CYD0692 for 24, 48, and 72 hours; cell viability was measured by Alamar Blue assay (B). P-values shown compared to vehicle (0.1% DMSO, 0 μM). The results are representative of at least three independent experiments.