Fig. 7.

Fenofibrate and ASO-Fsp27 reduce hepatic fibrosis. A: Relative expression of selected fibrotic transcripts. B: Representative polarized light micrographs of paraffin-embedded sections stained with Picrosirius red. Yellow-to-orange signal reveals the presence of zone 3 perisinusoidal collagen fibers, especially in the ASO-ctrl group. Scale bars represent 100 μm. Percentage collagen area was estimated from 10 random fields per experimental group. Data are shown as means ± SEM (n = 5). *P ≤ 0.05, **P ≤ 0.01, compared with (ASO-ctrl, saline); ^‡P ≤ 0.05, significant interaction between ASO-Fsp27 and fenofibrate treatments.