TABLE 1.

Demographics of extreme HDL-C patient cohorts

	Lipid Genetics Clinic				Montréal Heart Institute Biobank				University of Pennsylvania
	Low HDL-C		High HDL-C		Low HDL-C		High HDL-C		Low HDL-C		High HDL-C
	Males	Females	Males	Females	Males	Females	Males	Females	Males	Females	Males	Females
N	90	46	60	59	131	70	280	67	202	147	217	482
Age	48.1 ± 16.8a	45.4 ± 12.5a	58.5 ± 14.2	58.6 ± 10.5	64.4 ± 10.4	68.9 ± 8.4	65.6 ± 10.1	71.2 ± 7.2	56.0 ± 12.2	53.2 ± 15.0	58.7 ± 14.9	58.2 ± 11.7
BMI	29.0 ± 5.6a	28.8 ± 6.0a	26.5 ± 3.7	25.3 ± 3.5a	31.0 ± 5.2a	31.4 ± 6.4a	26.9 ± 4.5a	26.4 ± 6.0a	32.4 ± 5.0a	34.5 ± 7.4a	29.0 ± 5.0a	27.2 ± 7.0a
TC	4.2 ± 1.4	5.8 ± 2.3	5.7 ± 1.4	6.9 ± 1.5	3.4 ± 1.1	3.7 ± 1.0	4.5 ± 1.0a	5.2 ± 1.1	4.0 ± 1.1	4.5 ± 1.3	6.5 ± 1.6	6.4 ± 1.2
HDL-C	0.6 ± 0.2	0.8 ± 0.2	2.1 ± 0.5	2.7 ± 0.7	0.7 ± 0.1	0.9 ± 0.1	1.7 ± 0.2	2.1 ± 0.3	0.8 ± 0.2	0.9 ± 0.2	2.5 ± 0.5	2.9 ± 0.5
LDL-C	2.7 ± 1.3	4.0 ± 2.3	3.2 ± 1.4	3.7 ± 1.5	2.2 ± 1.0	2.2 ± 0.9	2.4 ± 0.9a	2.5 ± 0.9	2.7 ± 1.3	3.2 ± 1.7	3.0 ± 1.2	3.6 ± 2.0
TG	2.2 ± 1.3	2.0 ± 1.1	1.0 ± 0.5	1.2 ± 0.6	2.2 ± 0.7	2.3 ± 0.7	1.4 ± 0.6	1.3 ± 0.5	1.8 ± 0.7	1.6 ± 0.6	0.9 ± 0.4	0.9 ± 0.4
CVD Hx (%)	45.2a	21.9a	29.8a	16.7a	60.3	67.1	40.7	31.3	11.9a	12.9a	6.0a	4.1a

Values are indicative of the mean ± SD. Lipid values are in millimoles per liter. CVD Hx, CVD history; TC, total cholesterol.

^aAn incomplete dataset was used for these calculations.