TABLE 2.

Nine SNPs used in polygenic trait score

Chr:Position	rsID	Gene	High HDL-C-Associated Allele	Effect Size	Relation with HDL-C or HDL Metabolism
1:182199750	rs1689800	ZNF648	A	0.034	Mechanism underlying association is poorly characterized.
1:230159944	rs4846914	GALNT2	A	0.048	Recently confirmed as an important determinant of HDL-C (43)
9:104902020	rs1883025	ABCA1	C	0.07	Causative gene for Tangier disease (6)
12:109562388	rs7134594	MVK	T	0.035	MVK encodes mevalonate kinase, which is involved in biosynthesis of cholesterol and isoprenoids (44), although the closely linked MMAB gene encoding cob(I)alamin adenosyltransferase may actually underlie the HDL-C association at this locus (45).
12:124777047	rs838880	SCARB1	C	0.048	Causative gene for scavenger receptor B1 deficiency
15:58391167	rs1532085	LIPC	A	0.107	Causative gene for hepatic lipase deficiency
16:56959412	rs3764261	CETP	A	0.241	Causative gene for cholesteryl ester transfer protein deficiency
16:81501185	rs2925979	CMIP	C	0.035	Mechanism underlying association is poorly characterized.
19:8368312	rs7255436	ANGPTL4	A	0.032	Regulates LPL with reciprocal effects on triglycerides and HDL-C (46)

SNP information from this table has been extracted from (42). Chr, chromosome; rsID, reference SNP cluster ID (accession number).