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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Ann Biomed Eng. 2017 Jul 25;45(11):2626–2634. doi: 10.1007/s10439-017-1891-8

Figure 2.

Figure 2

Longitudinal quantitation by contrast-enhanced microCT revealed that changes of the IVD structure as a result of the stab- , trypsin-, and collagenase- administration. The treatment (p < 0.05) and incubation duration (p < 0.01) were significant factors that altered the change of disc height (Panel A; ANOVA), whole disc volume loss (Panel B; p < 0.01 [treatment]; p < 0.01 [incubation duration]; ANOVA), and whole disc attenuation loss (Panel C; p < 0.001 [treatment]; p < 0.001 [incubation duration]; ANOVA). In each of these factors, treatment and incubation time had an interactive effect that significantly contributed to these changes with p < 0.05 in all measurements. a - denotes p < 0.05 compared with the control group of the same incubation time. b - denotes p < 0.05 compared with the same treatment at zero day.