Table V.
Biomarker Correlations with Serum Direct Bilirubin
| Baseline Direct Bilirubin | 3 month Direct BilirubinI | 6 month Direct BilirubinII | |
|---|---|---|---|
| Linoleic acid | 0.21 (05) | −0.30 (0.3) | 0.03 (1) |
| α-linolenic acid | −0.07 (0.8) | 0.23 (0.46) | −0.20 (0.7) |
| Arachidonic acid | −0.57 (0.03) | −0.44 (0.1) | −0.17 (0.8) |
| Eicosapentaenoic acid | 0.02 (1) | 0.26 (0.4) | 0.43 (0.5) |
| Docosahexaenoic acid | −0.41 (0.1) | −0.33 (0.3) | 0.17 (0.8) |
| Stigmasterol | 0.60 (0.05) | 0.68 (0.03) | 0.50 (0.5) |
| Sitosterol | 0.27 (0.4) | 0.39 (0.3) | 0.91 (0.1) |
| Campesterol | −0.12 (0.7) | 0.06 (0.9) | −0.60 (0.4) |
| TNF-α | −0.09 (0.8) | 0.38 (0.2) | −0.25 (0.6) |
| IL-8 | 0.71 (<0.01) | 0.75 (<0.01) | 0.37 (0.5) |
| IL-10 | 0.03 (0.9) | 0.41 (0.2) | 0.16 (0.8) |
| IL-1β | −0.07 (0.8) | 0.25 (0.4) | −0.3 (0.6) |
| IL-6 | −0.19 (0.5) | −0.07 (0.8) | −0.21 (0.7) |
| IFN-γ | 0.38 (0.2) | 0.31 (0.4) | 0.14 (0.8) |
| Cholic acid | −0.38 (0.2) | −0.26 (0.4) | 0.38 (0.5) |
| Glycocholic acid | −0.16 (0.6) | −0.32 (0.3) | 0.62 (0.3) |
| Taurocholic acid | −0.04 (0.9) | −0.39 (0.3) III | 0.06 (0.9) |
| Total cholic acid | −0.03 (0.9) | −0.23 (0.4) III | 0.2 (0.7) |
| Chenodoxycholic acid | −0.35 (0.3) | −0.26 (0.4) | 0.37 (0.5) |
| Glycochenodoxycholic acid | 0.15 (0.6) | −0.25 (0.5) | −0.40 (0.5) |
| Taurochenodoxycholic acid | 0.52 (0.08) | −0.29 (0.4) | −0.47 (0.4) |
| Total chenodoxycholic acid | 0.45 (0.1) | 0.09 (0.8) | −0.55 (0.3) |
Correlations presented as Pearson correlation coefficients (p-value).
I
Two week biomarker (2 week – baseline) and 3 month direct bilirubin changes (3 month – baseline).
II
Three month biomarker changes (3 month – baseline) and six month direct bilirubin correlations (6 month – baseline).
III
Outlier was removed. When outlier was included, the results were r=−0.71 (p=0.02) for taurocholic acid, and r= −0.54 (p=0.04) and total cholic acid.