Fig. 2.

Molecules involved in the interactions between cancer cells and nerve cells. a Neurotrophic factors, neurotrophins (NGF, BDNF, NT3, and NT4) and their receptors (p75NTR, TrkA, TrkB, and Trkc). b Neurotrophic factors of the GDNF family (GDNF, ARTN, and NRTN) and their receptors (RET, GFRα1, GFRα2, and GFRα3). c Guidance molecules (CX3CL1 and CX3CR1, CCL2, and CCR2, NCAM1, L1CAM, Slit2, and Robo 1&2, PlexinB1, and Sema 4D&4F). d Other molecules [MMP2 and MMP9, MAG and MUC1, neurotransmitters norepinephrine (NE), and acetylcholine (Ach)]. N neuron, SC Schwann cell, CC cancer cell, CSC cancer stem cell, M macrophage. Full arrows show release of soluble factors by specific cell types. Dotted arrows point cell types that express corresponding receptors