Table 2.
Performance characteristics of urine COL4A1, COL13A1, and CYFRA 21‐1 in preoperative voided urine
| Performance characteristics | COL4A1 | COL13A1 | COL4A1 + COL13A1 | CYFRA21‐1 | NMP‐22 | VUC | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Alone (ng/mL) | Creatinine normalized (ng/mg Cre) | Alone (ng/mL) | Creatinine normalized (ng/mg Cre) | Alone (ng/mL) | Creatinine normalized (ng/mg Cre) | Alone (ng/mL) | Creatinine normalized (ng/mg Cre) | |||
| Area under ROC | 0.73 | 0.75 | 0.63 | 0.61 | 0.75 | 0.74 | 0.85 | 0.84 | NA | NA |
| Optimal cut‐off value | 0.84 | 9.62 | 0.51 | 3.85 | 1.33 | 15.92 | 1.27 | 15.92 | NA | NA |
| Total (n = 154) | ||||||||||
| Sensitivity (%) | 68.2 | 69.5 | 54.6 | 51.7 | 72.1 | 65.3 | 74.6 | 81.4 | 38.1 | 40.0 |
| Specificity (%) | 68.9 | 72.6 | 77.1 | 76.5 | 65.6 | 78.4 | 82.4 | 74.5 | NA | 100 |
| Positive predictive value (%) | 84.7 | 88.2 | 85.7 | 83.6 | 84.1 | 87.5 | 90.7 | 91.4 | NA | 100 |
| Negative predictive value (%) | 46.2 | 52.6 | 40.2 | 40.6 | 48.2 | 49.4 | 58.3 | 65.6 | NA | 52.1 |
| Accuracy (%) | 68.3 | 72.1 | 60.9 | 59.2 | 70.2 | 69.2 | 76.9 | 81.6 | NA | 74.7 |
| McNemar test, P‐value Alone vs creatinine normalized | 0.62 | 0.61 | 0.18 | 0.99 | NA | NA | ||||
| McNemar test, P‐value for comparison with VUC | <0.001 | <0.001 | 0.003 | 0.029 | <0.001 | 0.002 | <0.001 | <0.001 | NA | NA |
| Sensitivity (%) for grade/stage | ||||||||||
| Low‐grade (n = 68) | 57.4 | 55.6 | 35.3 | 33.9 | 57.4 | 48.2 | 62.5 | 69.6 | 22.2 | 17.6 |
| High‐grade (n = 86) | 76.7 | 79.0 | 69.8 | 67.7 | 83.7 | 80.6 | 85.5 | 91.9 | 54.0 | 58.1 |
| Ta (n = 66) | 56.1 | 55.6 | 33.3 | 31.5 | 56.1 | 37.9 | 47.0 | 56.1 | 18.2 | 16.7 |
| T1 (n = 57) | 79.0 | 80.7 | 63.2 | 70.2 | 80.7 | 80.7 | 89.5 | 94.7 | 52.6 | 56.1 |
| Isolated Tis (n = 7) | 85.7 | 85.7 | 57.1 | 57.1 | 85.7 | 85.7 | 85.7 | 85.7 | 71.4 | 57.1 |
| T2‐4 (n = 24) | 70.8 | 83.3 | 95.8 | 95.8 | 91.7 | 95.8 | 87.5 | 87.5 | 50.0 | 62.5 |
COL13A1, collagen type 13 alpha 1; COL4A1, collagen type 4 alpha 1; Cre, creatinine; CYFRA21‐1, fragments of cytokeratin‐19; NA, not analyzed; NMP‐22, nuclear matrix protein 22; ROC, receiver operating characteristic; VUC, voided urine cytology.