Figure 2.

Vascular remodeling effect of eribulin, but not vinorelbine, in human cancer cell xenograft models. Eribulin (ERI) and vinorelbine (VNR) were given by tail vein injection with Q4D2 schedule. Two days after the last administration of the anticancer agents, tumors were harvested and stained with CD31 and alpha‐smooth muscle actin (α‐SMA) antibodies. (a) Representative immunohistochemical staining with CD31 and α‐SMA in the HSAEC_4T53RD (HSAEC RD) and H1650 xenografted tumors. Brown, CD31, red, α‐SMA. (b) MVD in the xenografted tumor (n = 4). *P < 0.05.