Table 1.
Summary of the human angiosarcoma clinical cases assayed
| Case | Gender | Age | Site | Size (mm) | Nodal metastasis | Distant metastasis | Recurrence | Chemotherapy | Radiotherapy | Outcome | Survivin | YAP | Hippo |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A01 | Male | 82 | Scalp | 15 | + | + (lung) | Stationary | + (DTX) | + (70 Gy) | Death (7 months) | 2 | 0 | |
| A02 | Male | 61 | Right forehead | 10 | − | − | Stationary | + (DTX) | + (70 Gy) | Alive (24 months) | 2 | 0 | |
| A03 | Male | 89 | Scalp | 15 | − | + (lung) | Unknown | − | + (70 Gy) | Death (7 months) | 2 | 0 | |
| A04 | Male | 88 | Left forehead‐calvaria | 15 | + | + (bone) | Stationary | − | + (70 Gy) | Death (27 months) | 2 | 0 | |
| A05 | Male | 73 | Calvaria | 30 | − | + (lung, parotid gland) | + | + (DTX) | + (60 Gy) | Death (60 months) | 3 | 1 (N+cyto) | OFF |
| A06 | Female | 91 | Forehead‐calvaria | 200 | − | − | − | − | + (70 Gy) | Death (11 months) | 2 | 2 (N) | OFF |
| A07 | Female | 78 | Calvaria | 30 | − | − | − | + (DTX) | + (70 Gy) | Death (6 months) | 3 | 2 (N+cyto) | OFF |
| A08 | Female | 57 | Left forehead | 60 | − | − | − | + (DTX) | + (70 Gy) | Alive (38 months) | 3 | 2 (N+cyto) | OFF |
| A09 | Female | 67 | Left temple | 40 | − | − | − | + (DTX) | + (70 Gy) | Alive (38 months) | 2 | 0 | |
| A10 | Female | 73 | Calvaria | 50 | − | + (lung) | Stationary | − | + (70 Gy) | Death (6 months) | 1 | 1 (N) | OFF |
| A11 | Male | 80 | Scalp | 60 | − | + (lung) | − | + (DTX) | + (70 Gy) | Death (8 months) | 2 | 1 (N) | OFF |
| A12 | Female | 80 | Right chest | Unknown | Unknown | Unknown | Unknown | Unknown | Unknown | Unknown | 3 | 3 (N+cyto) | OFF |
| A13 | Male | 63 | Left forehead | 30 | − | + (lung) | − | + (DTX) | + (70 Gy) | Death (9 months) | 2 | 2 (N) | OFF |
| A14 | Male | 85 | Calvaria‐occiput | 20 | + | + (lung, parotid gland) | + | − | + (70 Gy) | Death (25 months) | 3 | 3 (N+cyto) | OFF |
| A15 | Male | 64 | Right submandibular | 10 | + | + (lung, liver) | + | + (DTX) | + (70 Gy) | Death (45 months) | 3 | 2 (N+cyto) | OFF |
| A16 | Male | 74 | Right forehead | 30 | + | + (lung, parotid gland, bone) | + | − | + (70 Gy) | Death (21 months) | 3 | 3 (N+cyto) | OFF |
| A17 | Male | 73 | Calvaria | 39 | − | + (lung, liver, adrenal gland, bone) | + | + (DTX) | + (60 Gy) | Death (21 months) | 1 | 1 (N) | OFF |
| A18 | Female | 92 | Right cheek | 34 | Unknown | + (lung) | + | − | + (60 Gy) | Death (15 months) | 2 | 1 (N) | OFF |
| A19 | Female | 73 | Left calvaria | 25 | Unknown | + (lung) | unknown | + (DTX) | − | Death (9 months) | 2 | 2 (N+cyto) | OFF |
| A20 | Male | 79 | Left temple | 50 | + | + (lung, liver) | stationary | − | − | Death (10 months) | 2 | 2 (N+cyto) | OFF |
| A21 | Male | 73 | Calvaria | 35 | Unknown | unknown | stationary | − | − | Unknown | 2 | 2 (cyto) | ON |
| A22 | Female | 81 | Calvaria | 80 | − | − | stationary | − | + (20 Gy) | Death (2 months) | 2 | 2 (N+cyto) | OFF |
| A23 | Male | 85 | Occiput | 20 | − | + (lung) | + | − | + (178 Gy) | Death (82 months) | 2 | 0 | |
| A24 | Male | 78 | Calvaria | 26 | Unknown | + (lung) | + | − | + (70 Gy) | Death (17 months) | 3 | 3 (N+cyto) | OFF |
| A25 | Male | 85 | Calvaria | 40 | + | + (lung) | Unknown | − | + (60 Gy) | Death (14 months) | 3 | 2 (N+cyto) | OFF |
| A26 | Male | 75 | Calvaria | 37 | Unknown | + (lung, liver, spleen) | Unknown | + (DTX) | + (60 Gy) | Death (4 months) | 3 | 3 (N+cyto) | OFF |
| A27 | Male | 75 | Calvaria | 24 | − | + (lung, liver, spleen) | Unknown | − | − | Death (11 months) | 2 | 2 (N) | OFF |
| A28 | Female | 87 | Calvaria | 30 | Unknown | + (lung) | Unknown | + (DTX) | − | Death (3 months) | 3 | 1 (cyto) | ON |
| A29 | Male | 75 | Forehead | 150 | − | + (lung) | + | + (DTX) | + (70 Gy) | Death (26 months) | 2 | 1 (cyto) | ON |
| A30 | Female | 78 | Calvaria | 120 | Unknown | + (lung, bone) | + | + (DTX) | + (70 Gy) | Death (21 months) | 2 | 2 (N) | OFF |
| A31 | Female | 75 | Posterior auricle | 50 | − | + (parotid gland) | + | + (DTX) | + (70 Gy) | Death (92 months) | 2 | 2 (N+cyto) | OFF |
| A32 | Male | 58 | Posterior auricle | 50 | Unknown | + (lung) | Unknown | + (DTX) | + (70 Gy) | Death (49 months) | 2 | 3 (N+cyto) | OFF |
| A33 | Male | 74 | Forehead | 140 | − | + (lung) | Stationary | − | + (60 Gy) | Death (9 months) | 3 | 3 (cyto) | ON |
| A34 | Female | 93 | Calvaria | 32 | + | − | + | − | + (60 Gy) | Death (13 months) | 3 | 2 (N) | OFF |
| A35 | Male | 81 | Calvaria | 30 | + | + (lung) | Stationary | − | + (7 Gy) | Death (5 months) | 3 | 2 (N+cyto) | OFF |
| A36 | Female | 96 | Calvaria | 30 | − | − | Unknown | − | + (70 Gy) | Unknown | 3 | 3 (cyto) | ON |
| A37 | Male | 76 | Calvaria | 15 | − | + (spleen) | Stationary | + (DTX) | + (70 Gy) | Death (22 months) | 2 | 0 | |
| A38 | Male | 86 | Forehead | 20 | − | − | Stationary | + (DTX) | + (70 Gy) | Unknown | 2 | 0 | |
| A39 | Male | 75 | Scalp | 60 | − | + (lung) | − | + (DTX) | + (70 Gy) | Death (11 months) | 2 | 0 | |
| A40 | Male | 75 | Forehead | 20 | + | − | − | + (DTX) | − | Death (17 months) | 2 | 0 | |
| A41 | Female | 86 | Forehead | 70 | Unknown | unknown | Unknown | unknown | unknown | Death (19 months) | 1 | 2 (N) | OFF |
| A42 | Male | 71 | Calvaria | 35 | − | + (lung, small intestine) | Unknown | − | + (28 Gy) | Death (10 months) | 2 | 3 (N+cyto) | OFF |
| A43 | Male | 70 | Forehead | 150 | − | + (lung, bone) | Stationary | + (DTX) | + (60 Gy) | Death (4 months) | 1 | 2 (N) | OFF |
| A44 | Male | 75 | Forehead | 143 | + | + (lung) | + | + (DTX) | + (60 Gy) | Death (16 months) | 1 | 2 (N+cyto) | OFF |
| A45 | Male | 78 | Calvaria | 15 | − | + (lung) | + | + (DTX) | + (70 Gy) | Death (16 months) | 1 | 2 (N) | OFF |
| A46 | Male | 78 | Forehead | 80 | − | + (lung, liver) | Stationary | + (DTX) | + (70 Gy) | Death (7 months) | 1 | 1 (N) | OFF |
| A47 | Male | 59 | Scalp | 20 | − | − | − | − | − | Alive | 1 | 1 (cyto) | ON |
| A48 | Male | 65 | Neck | 29 | + | + (liver) | − | + | − | Alive | 1 | 1 (N) | OFF |
| A49 | Male | 60 | Scalp | 210 | − | − | − | − | − | Alive | 3 | 2 (N) | OFF |
| A50 | Male | 78 | Face | Unknown | − | − | − | + | + | Alive | 3 | 0 | |
| A51 | Male | 71 | Occiput | 40 | − | − | + | − | + (50 Gy) | Alive | 3 | 2 (N+cyto) | OFF |
| A52 | Male | 80 | Forehead | 100 | + | + (lung, liver) | + | − | + (60 Gy) | Death (15 months) | 3 | 1 (N) | OFF |
| A53 | Male | 79 | Face | Unknown | − | − | Stationary | − | − | Death (6 months) | 3 | 2 (N+cyto) | OFF |
| A54 | Male | 75 | Left temple‐neck | Unknown | + | + (lung) | Stationary | + (DTX) | + | Death (2 months) | 3 | 0 | |
| A55 | Female | 87 | Left forehead | 80 | Unknown | + (lung, bone) | Stationary | + (DTX) | + (60 Gy) | Death (6 months) | 1 | 1 (N) | OFF |
| A56 | Male | 63 | Left temple | 25 | − | − | + | + (DTX) | + | Alive | 1 | 2 (N) | OFF |
| A57 | Male | 76 | Occiput | 35 | − | + (lung) | Stationary | + (DTX) | + | Death (18 months) | 2 | 1 (N) | OFF |
| A58 | Male | 87 | Left forehead | 60 | − | − | − | − | + | Alive | 2 | 1 (N) | OFF |
| A59 | Female | 62 | Scalp | 25 | − | + (lung, femur) | − | − | + | Death (6 months) | 2 | 1 (N) | OFF |
| A60 | Male | 82 | Scalp | 165 | − | − | − | − | − | Alive | 2 | 1 (N+cyto) | OFF |
| A61 | Male | 66 | Left forehead | 100 | − | − | + | + (DTX) | − | Alive | 3 | 3 (N+cyto) | OFF |
| A62 | Male | 77 | Forehead | 40 | − | − | + | + (DTX) | + | alive | 2 | 1 (N+cyto) | OFF |
| A63 | Male | 77 | Left calvaria | 60 | − | − | + | + (DTX) | + | Alive | 3 | 2 (N) | OFF |
| A64 | Male | 76 | Calvaria | 220 | − | + (bone) | + | + (DTX) | + | Death (24 months) | 3 | 2 (N+cyto) | OFF |
| A65 | Male | 77 | Right calvaria | 100 | + | + (lung) | + | + (DTX) | + | Death (36 months) | 3 | 0 | |
| A66 | Male | 60 | Left calvaria | 50 | + | − | Stationary | + (DTX) | + | Death (18 months) | 3 | 2 (N) | OFF |
| A67 | Male | 72 | Left calvaria | 37 | − | − | + | + (DTX) | + | Death (48 months) | 2 | 2 (N) | OFF |
| A68 | Female | 50 | Occiput | 22 | + | + (lung, bone, pancreas, peritoneum) | + | + (DTX) | + | Death (48 months) | 3 | 1 (N) | OFF |
| A69 | Male | 86 | Calvaria | 80 | − | − | − | + (DTX) | + | Alive | 2 | 2 (N+cyto) | OFF |
| A70 | Female | 61 | Left temple | 37 | − | + (bone, liver) | + | + (DTX) | + | Death (24 months) | 3 | 1 (N) | OFF |
| A71 | Female | 64 | Left temple | 40 | + | − | Stationary | + (DTX) | + | Alive | 3 | 2 (N+cyto) | OFF |
| A72 | Female | 62 | Scalp | 20 | − | − | − | − | − | Alive | 3 | 1 (N) | OFF |
| A73 | Female | 63 | Calvaria | 20 | + | − | − | − | + | Alive | 3 | 1 (N+cyto) | OFF |
| A74 | Male | 80 | Calvaria | 40 | − | − | + | + (DTX) | + | Alive | 3 | 1 (N+cyto) | OFF |
| A75 | Male | 74 | Left forehead | 90 | − | + (bone) | Stationary | + (DTX) | + | Death (12 months) | 2 | 1 (N+cyto) | OFF |
| A76 | Female | 74 | Chest | 90 | − | + (liver) | + | − | + | Death | 2 | 3 (N+cyto) | OFF |
| A77 | Female | 55 | Forearm | 15 | Unknown | − | + | − | − | Death | 1 | 1 (N) | OFF |
| A78 | Female | 67 | Groin | 67 | + | + (lung, peritoneal cavity, intestine) | + | + (DTX) | − | Death | 2 | 2 (N+cyto) | OFF |
| A79 | Female | 70 | Foot | 12 | + | + (scalp, retroperitoneum) | − | − | + | Death | 3 | 2 (N+cyto) | OFF |
| A80 | Female | 64 | Lower leg | 10 | + | + (femur) | − | − | − | Death | 2 | 2 (N+cyto) | OFF |
| A81 | Male | 61 | Unknown | 61 | − | + (bone) | − | + (wPTX) | − | Unknown | 2 | 2 (cyto) | ON |
| A82 | Female | 36 | Dorsal skin | 42 | − | + (bone) | − | − | + | Alive | 3 | 3 (N+cyto) | OFF |
| A83 | Female | 42 | Femur | 35 | − | − | − | − | − | Alive | 2 | 2 (N+cyto) | OFF |
| A84 | Male | 77 | Shoulder | 85 | + | + (scalp) | + | − | + | Death | 3 | 3 (N+cyto) | OFF |
| A85 | Male | 16 | Lower leg | 20 | + | + (femur, skin) | + | + (DXR) | + | Death | 3 | 1 (N) | OFF |
DTX, docetaxel; DXR, doxorubicin (Adriamycin); outcome, months after diagnosed; survivin, nuclear positivity; YAP, nuclear (N) and cytoplasmic (cyto) positivity; wPTX, weekly paclitaxel. Score 0 (no staining), 1 (faint/barely staining in tumor cells), 2 (weak to moderate staining in 10–50% of the tumor cells) or 3 (uniform intense staining in over 50% of the tumor cells).