Table 2.

Stability of peptide-inhibitors to proteolysis. √, stable; X, degraded, after 3 h incubation with the enzyme.

	IO8	RI-IO8	N1-IO8	N2-IO8
blood plasma	X	√	√	√
trypsin	X	√	√a	√a
chymotrypsin	X	√	√	√
cathepsin G	X	√	√	√
elastase	X	√	√	√
thrombin	X	√	√a	√
kallikrein	X	√	√a	√a
plasmin	X	√	√	√
factor X	X	√	√	√

^aSome degradation seen after 24 h incubation. HPLC traces for IO8, N1-IO8 and N2-IO8 are given in electronic supplementary material, figure S3.