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(a) Model substructure in the multiscale method. Eight RVEs are embedded on each Gauss point of the macroscopic finite elements. Each RVE is composed of a fibre network and a neo-Hookean matrix. (b) Model geometry of an embedded axon in a continuous ECM, along with boundary conditions for transverse loading case. In comparison with the corresponding discrete-fibre model, only one quarter of the axon and ECM is modelled. (Online version in colour.)
