Figure 4.

LP17 attenuated the increased level of pJAK2 and pSTAT3 in kidney. (A) Relative mRNA of JAK2 (left) and STAT3 (right) were detected by real-time PCR at the time point of 0 h, 12 h, 24 h, and 48 h. (B) The protein levels of JAK2/pJAK2 (left) and STAT3/pSTAT3 (right) were measured by Western blotting 48 h after first administration of saline, scrambled peptide, or LP17. NC, normal rats receiving saline; CLP-Scrambled peptides, rats with sepsis receiving scrambled peptide; CLP-LP17, rats with sepsis receiving LP17.